Names & Taxonomy

Uniprot ID:
Q8TD30
Entry Name:
ALAT2_HUMAN
Status:
reviewed
Protein Names:
Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
Gene Names:
GPT2 AAT2 ALT2
Gene Names Primary:
GPT2
Organism:
Homo sapiens (Human)

Structure

Length:
523
Sequence:
MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA
Proteomes:
UP000005640

Function

Function:
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
Pathway:
Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
Catalytic Activity:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Cross Reference Drug Bank:
DB00160 DB00780
Gene Ontology Go:
mitochondrial matrix
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
2-oxoglutarate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
L-alanine metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
2-oxoglutarate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
L-alanine metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
3D-structure
Acetylation
Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Mental retardation
Pyridoxal phosphate
Reference proteome
Transferase

Publication

PubMed ID:
11863375 14702039 15616553 15489334 21269460 25758935