Names & Taxonomy
- Uniprot ID:
- Q8TCU5
- Entry Name:
- NMD3A_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)
- Gene Names:
- GRIN3A KIAA1973
- Gene Names Primary:
- GRIN3A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1115
- Sequence:
- MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB06151 DB00915 DB00289 DB01161 DB00514 DB00898 DB00392 DB00949 DB00996 DB01159 DB01221 DB06738 DB01043 DB00333 DB04896 DB01173 DB00312 DB01174 DB00721 DB00418 DB00193
- Gene Ontology Go:
- cell junction
integral component of membrane
membrane
neuron projection
neuronal cell body
NMDA selective glutamate receptor complex
postsynaptic density
postsynaptic membrane
synapse
calcium channel activity
extracellular-glutamate-gated ion channel activity
glycine binding
identical protein binding
NMDA glutamate receptor activity
protein phosphatase 2A binding
calcium ion transport
dendrite development
ionotropic glutamate receptor signaling pathway
prepulse inhibition
response to ethanol - Gene Ontology Biological Process:
- calcium ion transport
dendrite development
ionotropic glutamate receptor signaling pathway
prepulse inhibition
response to ethanol - Gene Ontology Molecular Function:
- calcium channel activity
extracellular-glutamate-gated ion channel activity
glycine binding
identical protein binding
NMDA glutamate receptor activity
protein phosphatase 2A binding - Gene Ontology Cellular Component:
- cell junction
integral component of membrane
membrane
neuronal cell body
neuron projection
NMDA selective glutamate receptor complex
postsynaptic density
postsynaptic membrane
synapse - Keywords:
- Calcium
Cell junction
Cell membrane
Coiled coil
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport