Names & Taxonomy
- Uniprot ID:
- Q8TCT8
- Entry Name:
- SPP2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
- Gene Names:
- SPPL2A IMP3 PSL2 PSEC0147
- Gene Names Orf:
- PSEC0147
- Gene Names Primary:
- SPPL2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 520
- Sequence:
- MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Late endosome membrane
Function
- Function:
- Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
- Active Site:
- ACT_SITE 351 351
- Gene Ontology Go:
- extracellular exosome
Golgi-associated vesicle membrane
integral component of cytoplasmic side of endoplasmic reticulum membrane
integral component of lumenal side of endoplasmic reticulum membrane
intracellular membrane-bounded organelle
late endosome
late endosome membrane
lysosomal membrane
membrane
plasma membrane
aspartic endopeptidase activity, intramembrane cleaving
protein homodimerization activity
membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
regulation of immune response - Gene Ontology Biological Process:
- membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
regulation of immune response - Gene Ontology Molecular Function:
- aspartic endopeptidase activity, intramembrane cleaving
protein homodimerization activity - Gene Ontology Cellular Component:
- extracellular exosome
Golgi-associated vesicle membrane
integral component of cytoplasmic side of endoplasmic reticulum membrane
integral component of lumenal side of endoplasmic reticulum membrane
intracellular membrane-bounded organelle
late endosome
late endosome membrane
lysosomal membrane
membrane
plasma membrane - Keywords:
- Complete proteome
Endosome
Glycoprotein
Hydrolase
Lysosome
Membrane
Polymorphism
Protease
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- O43765