Names & Taxonomy

Uniprot ID:
Q8TCT1
Entry Name:
PHOP1_HUMAN
Status:
reviewed
Protein Names:
Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)
Gene Names:
PHOSPHO1
Gene Names Primary:
PHOSPHO1
Organism:
Homo sapiens (Human)

Structure

Length:
267
Sequence:
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC
Proteomes:
UP000005640

Function

Function:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
Catalytic Activity:
O-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3 uM for PEA
Active Site:
ACT_SITE 32 32 Nucleophile.
Cross Reference Drug Bank:
DB00122
Gene Ontology Go:
cytosol
extracellular membrane-bounded organelle
proteinaceous extracellular matrix
metal ion binding
phosphatase activity
phosphocholine phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity
bone mineralization involved in bone maturation
dephosphorylation
endochondral ossification
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
regulation of bone mineralization
small molecule metabolic process
Gene Ontology Biological Process:
bone mineralization involved in bone maturation
dephosphorylation
endochondral ossification
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
regulation of bone mineralization
small molecule metabolic process
Gene Ontology Molecular Function:
metal ion binding
phosphatase activity
phosphocholine phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity
Gene Ontology Cellular Component:
cytosol
extracellular membrane-bounded organelle
proteinaceous extracellular matrix
Keywords:
Alternative splicing
Complete proteome
Hydrolase
Magnesium
Metal-binding
Mineral balance
Reference proteome

Publication

PubMed ID:
12464021 18471996 16625196 15489334 15175005 15050893 14983068 16054448