Names & Taxonomy
- Uniprot ID:
- Q8TCT1
- Entry Name:
- PHOP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)
- Gene Names:
- PHOSPHO1
- Gene Names Primary:
- PHOSPHO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 267
- Sequence:
- MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC
- Proteomes:
- UP000005640
Function
- Function:
- Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
- Catalytic Activity:
- O-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3 uM for PEA
- Active Site:
- ACT_SITE 32 32 Nucleophile.
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- cytosol
extracellular membrane-bounded organelle
proteinaceous extracellular matrix
metal ion binding
phosphatase activity
phosphocholine phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity
bone mineralization involved in bone maturation
dephosphorylation
endochondral ossification
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
regulation of bone mineralization
small molecule metabolic process - Gene Ontology Biological Process:
- bone mineralization involved in bone maturation
dephosphorylation
endochondral ossification
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
regulation of bone mineralization
small molecule metabolic process - Gene Ontology Molecular Function:
- metal ion binding
phosphatase activity
phosphocholine phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity - Gene Ontology Cellular Component:
- cytosol
extracellular membrane-bounded organelle
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Complete proteome
Hydrolase
Magnesium
Metal-binding
Mineral balance
Reference proteome