Names & Taxonomy

Uniprot ID:
Q8TC12
Entry Name:
RDH11_HUMAN
Status:
reviewed
Protein Names:
Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)
Gene Names:
RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82
Gene Names Orf:
CGI-82
Gene Names Primary:
RDH11
Organism:
Homo sapiens (Human)

Structure

Length:
318
Sequence:
MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGLPID
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
Catalytic Activity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.23 uM for NADPH
Active Site:
ACT_SITE 202 202 Proton acceptor.
Cross Reference Drug Bank:
DB00162
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
intracellular
photoreceptor inner segment
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
adaptation of rhodopsin mediated signaling
fat-soluble vitamin metabolic process
phototransduction, visible light
retinal metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
vitamin metabolic process
Gene Ontology Biological Process:
adaptation of rhodopsin mediated signaling
fat-soluble vitamin metabolic process
phototransduction, visible light
retinal metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
vitamin metabolic process
Gene Ontology Molecular Function:
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
intracellular
photoreceptor inner segment
Keywords:
Acetylation
Alternative splicing
Cataract
Complete proteome
Dwarfism
Endoplasmic reticulum
Membrane
NADP
Oxidoreductase
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11245473 10810093 14702039 16303743 12508121 15489334 17286855 12036956 19608861 21269460 24916380 24275569 25944712