Names & Taxonomy
- Uniprot ID:
- Q8TAD4
- Entry Name:
- ZNT5_HUMAN
- Status:
- reviewed
- Protein Names:
- Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1)
- Gene Names:
- SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879
- Gene Names Orf:
- UNQ863/PRO1879
- Gene Names Primary:
- SLC30A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 765
- Sequence:
- MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, trans-Golgi network membrane
Function
- Function:
- Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
- Gene Ontology Go:
- apical plasma membrane
Golgi apparatus
integral component of plasma membrane
membrane
nucleolus
nucleus
secretory granule
secretory granule membrane
zinc ion binding
zinc ion transmembrane transporter activity
cellular protein metabolic process
cellular zinc ion homeostasis
cobalt ion transport
regulation of proton transport
regulation of sequestering of zinc ion
response to zinc ion
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transport - Gene Ontology Biological Process:
- cellular protein metabolic process
cellular zinc ion homeostasis
cobalt ion transport
regulation of proton transport
regulation of sequestering of zinc ion
response to zinc ion
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transport - Gene Ontology Molecular Function:
- zinc ion binding
zinc ion transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
Golgi apparatus
integral component of plasma membrane
membrane
nucleolus
nucleus
secretory granule
secretory granule membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Golgi apparatus
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport
Zinc
Zinc transport