Names & Taxonomy
- Uniprot ID:
- Q8NI22
- Entry Name:
- MCFD2_HUMAN
- Status:
- reviewed
- Protein Names:
- Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)
- Gene Names:
- MCFD2 SDNSF
- Gene Names Primary:
- MCFD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 146
- Sequence:
- MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum-Golgi intermediate compartment
Function
- Function:
- The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
- Cross Reference Drug Bank:
- DB00025
- Gene Ontology Go:
- endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle membrane
Golgi membrane
calcium ion binding
cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
protein transport - Gene Ontology Biological Process:
- cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
protein transport - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum membrane
ER to Golgi transport vesicle membrane
Golgi membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Disease mutation
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Signal
Transport