Names & Taxonomy
- Uniprot ID:
- Q8NG66
- Entry Name:
- NEK11_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)
- Gene Names:
- NEK11
- Gene Names Primary:
- NEK11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 645
- Sequence:
- MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYADAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSLDTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNASEAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
Function
- Function:
- Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Enzyme Regulation:
- ENZYME REGULATION: Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc.
- Active Site:
- ACT_SITE 158 158 Proton acceptor.
- Cross Reference Drug Bank:
- DB08912
- Gene Ontology Go:
- nucleolus
nucleoplasm
ATP binding
metal ion binding
protein serine/threonine kinase activity
G2 DNA damage checkpoint
histone phosphorylation
intra-S DNA damage checkpoint
intracellular signal transduction
mitotic cell cycle phase transition
protein phosphorylation
regulation of mitotic cell cycle phase transition - Gene Ontology Biological Process:
- G2 DNA damage checkpoint
histone phosphorylation
intracellular signal transduction
intra-S DNA damage checkpoint
mitotic cell cycle phase transition
protein phosphorylation
regulation of mitotic cell cycle phase transition - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- nucleolus
nucleoplasm - Keywords:
- ATP-binding
Alternative splicing
Cell cycle
Coiled coil
Complete proteome
Kinase
Magnesium
Manganese
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- P51955; P51955-1