Names & Taxonomy
- Uniprot ID:
- Q8NFJ5
- Entry Name:
- RAI3_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)
- Gene Names:
- GPRC5A GPCR5A RAI3 RAIG1
- Gene Names Primary:
- GPRC5A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 357
- Sequence:
- MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
- Cross Reference Drug Bank:
- DB00755
- Gene Ontology Go:
- cytoplasmic vesicle membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
G-protein coupled receptor activity
negative regulation of epidermal growth factor-activated receptor activity
signal transduction - Gene Ontology Biological Process:
- negative regulation of epidermal growth factor-activated receptor activity
signal transduction - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
- Gene Ontology Cellular Component:
- cytoplasmic vesicle membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Cytoplasmic vesicle
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Tumor suppressor