Names & Taxonomy
- Uniprot ID:
- Q8NEB9
- Entry Name:
- PK3C3_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
- Gene Names:
- PIK3C3 VPS34
- Gene Names Primary:
- PIK3C3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 887
- Sequence:
- MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Midbody
Function
- Function:
- Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
- Catalytic Activity:
- ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Gene Ontology Go:
- autophagosome
axoneme
cytosol
late endosome
membrane
midbody
peroxisome
phagocytic vesicle membrane
phosphatidylinositol 3-kinase complex, class III
phosphatidylinositol 3-kinase complex, class III, type I
phosphatidylinositol 3-kinase complex, class III, type II
pre-autophagosomal structure
1-phosphatidylinositol-3-kinase activity
ATP binding
protein kinase activity
autophagosome assembly
cellular response to glucose starvation
cytokinesis
early endosome to late endosome transport
endocytosis
endosome organization
innate immune response
insulin receptor signaling pathway
macroautophagy
pexophagy
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
protein phosphorylation
protein processing
regulation of cytokinesis
regulation of protein secretion
response to leucine
small GTPase mediated signal transduction
small molecule metabolic process
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- autophagosome assembly
cellular response to glucose starvation
cytokinesis
early endosome to late endosome transport
endocytosis
endosome organization
innate immune response
insulin receptor signaling pathway
macroautophagy
pexophagy
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
protein phosphorylation
protein processing
regulation of cytokinesis
regulation of protein secretion
response to leucine
small GTPase mediated signal transduction
small molecule metabolic process
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase activity
ATP binding
protein kinase activity - Gene Ontology Cellular Component:
- autophagosome
axoneme
cytosol
late endosome
membrane
midbody
peroxisome
phagocytic vesicle membrane
phosphatidylinositol 3-kinase complex, class III
phosphatidylinositol 3-kinase complex, class III, type I
phosphatidylinositol 3-kinase complex, class III, type II
pre-autophagosomal structure - Keywords:
- 3D-structure
ATP-binding
Autophagy
Cell cycle
Cell division
Complete proteome
Cytoplasmic vesicle
Endosome
Kinase
Manganese
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase - Interacts With:
- Q6ZNE5; Q14457; Q96F24; Q92622; Q9P2Y5