Names & Taxonomy
- Uniprot ID:
- Q8NE62
- Entry Name:
- CHDH_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)
- Gene Names:
- CHDH
- Gene Names Primary:
- CHDH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 594
- Sequence:
- MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPKDVLAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRYRGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSAACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLRKVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAYQVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAPFRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Pathway:
- Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
- Catalytic Activity:
- Choline + acceptor = betaine aldehyde + reduced acceptor.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Active Site:
- ACT_SITE 511 511 Proton acceptor.
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- mitochondrial inner membrane
choline dehydrogenase activity
flavin adenine dinucleotide binding
glycine betaine biosynthetic process from choline - Gene Ontology Biological Process:
- glycine betaine biosynthetic process from choline
- Gene Ontology Molecular Function:
- choline dehydrogenase activity
flavin adenine dinucleotide binding - Gene Ontology Cellular Component:
- mitochondrial inner membrane
- Keywords:
- Acetylation
Complete proteome
FAD
Flavoprotein
Membrane
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide - Interacts With:
- Q7Z3S9