Names & Taxonomy
- Uniprot ID:
- Q8N8N7
- Entry Name:
- PTGR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)
- Gene Names:
- PTGR2 ZADH1
- Gene Names Primary:
- PTGR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
- Catalytic Activity:
- 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=11.21 uM for 15-keto-PGE2
- Cross Reference Drug Bank:
- DB00328
- Gene Ontology Go:
- cytoplasm
extracellular exosome
13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity
prostaglandin metabolic process - Gene Ontology Biological Process:
- prostaglandin metabolic process
- Gene Ontology Molecular Function:
- 13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
NADP
Oxidoreductase
Reference proteome