Names & Taxonomy
- Uniprot ID:
- Q8N568
- Entry Name:
- DCLK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
- Gene Names:
- DCLK2 DCAMKL2 DCDC3B DCK2
- Gene Names Primary:
- DCLK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 766
- Sequence:
- MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Function
- Function:
- Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Active Site:
- ACT_SITE 515 515 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytoskeleton
ATP binding
protein serine/threonine kinase activity
hippocampus development
intracellular signal transduction
pyramidal neuron development - Gene Ontology Biological Process:
- hippocampus development
intracellular signal transduction
pyramidal neuron development - Gene Ontology Molecular Function:
- ATP binding
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Serine/threonine-protein kinase
Transferase