Names & Taxonomy
- Uniprot ID:
- Q8N442
- Entry Name:
- GUF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase)
- Gene Names:
- GUF1
- Gene Names Primary:
- GUF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 669
- Sequence:
- MWTLVGRGWGCARALAPRATGAALLVAPGPRSAPTLGAAPESWATDRLYSSAEFKEKLDMSRFPVENIRNFSIVAHVDHGKSTLADRLLELTGTIDKTKNNKQVLDKLQVERERGITVKAQTASLFYNCEGKQYLLNLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEGIQAQTVANFFLAFEAQLSVIPVINKIDLKNADPERVENQIEKVFDIPSDECIKISAKLGTNVESVLQAIIERIPPPKVHRKNPLRALVFDSTFDQYRGVIANVALFDGVVSKGDKIVSAHTQKTYEVNEVGVLNPNEQPTHKLYAGQVGYLIAGMKDVTEAQIGDTLCLHKQPVEPLPGFKSAKPMVFAGMYPLDQSEYNNLKSAIEKLTLNDSSVTVHRDSSLALGAGWRLGFLGLLHMEVFNQRLEQEYNASVILTTPTVPYKAVLSSSKLIKEHREKEITIINPAQFPDKSKVTEYLEPVVLGTIITPDEYTGKIMMLCEARRAVQKNMIFIDQNRVMLKYLFPLNEIVVDFYDSLKSLSSGYASFDYEDAGYQTAELVKMDILLNGNTVEELVTVVHKDKAHSIGKAICERLKDSLPRQLFEIAIQAAIGSKIIARETVKAYRKNVLAKCYGGDITRKMKLLKRQAEGKKKLRKIGNVEVPKDAFIKVLKTQSSK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
- Catalytic Activity:
- GTP + H(2)O = GDP + phosphate.
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrion
GTP binding
GTPase activity
translation - Gene Ontology Biological Process:
- translation
- Gene Ontology Molecular Function:
- GTPase activity
GTP binding - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrion - Keywords:
- Complete proteome
GTP-binding
Hydrolase
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide
Ubl conjugation