Names & Taxonomy
- Uniprot ID:
- Q8N3U4
- Entry Name:
- STAG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)
- Gene Names:
- STAG2 SA2
- Gene Names Primary:
- STAG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1231
- Sequence:
- MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNGGGKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTGKRKVVEGMQLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQTEHHQTPLDYNRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERTELKPDFFDPASIMDESVLGVSMF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
Function
- Function:
- Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
- Gene Ontology Go:
- actin cytoskeleton
chromatin
chromosome
chromosome, centromeric region
cytosol
intermediate filament cytoskeleton
membrane
nucleolus
nucleoplasm
nucleus
plasma membrane
cell division
cellular protein metabolic process
meiotic cell cycle
mitotic cell cycle
mitotic nuclear division
negative regulation of DNA endoreduplication
post-translational protein modification
protein sumoylation
sister chromatid cohesion - Gene Ontology Biological Process:
- cell division
cellular protein metabolic process
meiotic cell cycle
mitotic cell cycle
mitotic nuclear division
negative regulation of DNA endoreduplication
post-translational protein modification
protein sumoylation
sister chromatid cohesion - Gene Ontology Cellular Component:
- actin cytoskeleton
chromatin
chromosome
chromosome, centromeric region
cytosol
intermediate filament cytoskeleton
membrane
nucleolus
nucleoplasm
nucleus
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Complete proteome
Meiosis
Mitosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q29RF7; Q9NTI5; Q9UQE7; Q9NP77