Names & Taxonomy

Uniprot ID:
Q8N2S1
Entry Name:
LTBP4_HUMAN
Status:
reviewed
Protein Names:
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
Gene Names:
LTBP4
Gene Names Primary:
LTBP4
Organism:
Homo sapiens (Human)

Structure

Length:
1624
Sequence:
MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix

Function

Function:
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM) (By similarity).
Gene Ontology Go:
cell
extracellular exosome
extracellular matrix
extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
glycosaminoglycan binding
integrin binding
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
extracellular matrix organization
growth hormone secretion
multicellular organism development
protein folding
regulation of cell differentiation
regulation of cell growth
regulation of proteolysis
regulation of transforming growth factor beta receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
Gene Ontology Biological Process:
extracellular matrix organization
growth hormone secretion
multicellular organism development
protein folding
regulation of cell differentiation
regulation of cell growth
regulation of proteolysis
regulation of transforming growth factor beta receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
Gene Ontology Molecular Function:
calcium ion binding
glycosaminoglycan binding
integrin binding
transforming growth factor beta-activated receptor activity
transforming growth factor beta binding
Gene Ontology Cellular Component:
cell
extracellular exosome
extracellular matrix
extracellular region
extracellular space
proteinaceous extracellular matrix
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Interacts With:
O15265; O00555

Publication

PubMed ID:
9271198 9660815 14702039 15057824 16157329 24275569 19836010