Names & Taxonomy
- Uniprot ID:
- Q8N1Q1
- Entry Name:
- CAH13_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII)
- Gene Names:
- CA13
- Gene Names Primary:
- CA13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 262
- Sequence:
- MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH
- Proteomes:
- UP000005640
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=13.8 mM for CO(2)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by acetazolamide.
- Active Site:
- ACT_SITE 65 65 Proton acceptor.
- Cross Reference Drug Bank:
- DB00909
- Gene Ontology Go:
- cytosol
intracellular membrane-bounded organelle
myelin sheath
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
intracellular membrane-bounded organelle
myelin sheath - Keywords:
- 3D-structure
Complete proteome
Lyase
Metal-binding
Polymorphism
Reference proteome
Zinc