Names & Taxonomy
- Uniprot ID:
- Q8N119
- Entry Name:
- MMP21_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-21 (MMP-21) (EC 3.4.24.-)
- Gene Names:
- MMP21
- Gene Names Primary:
- MMP21
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 569
- Sequence:
- MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 284 284
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular matrix
extracellular region
calcium ion binding
metalloendopeptidase activity
zinc ion binding
coronary vasculature development
determination of left/right symmetry
hematopoietic progenitor cell differentiation - Gene Ontology Biological Process:
- coronary vasculature development
determination of left/right symmetry
hematopoietic progenitor cell differentiation - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular matrix
extracellular region - Keywords:
- Calcium
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen