Names & Taxonomy
- Uniprot ID:
- Q8N0U8
- Entry Name:
- VKORL_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)
- Gene Names:
- VKORC1L1
- Gene Names Primary:
- VKORC1L1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 176
- Sequence:
- MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
- Catalytic Activity:
- Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by warfarin (coumadin).
- Cross Reference Drug Bank:
- DB00170
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
cellular response to oxidative stress
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- cellular response to oxidative stress
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Disulfide bond
Endoplasmic reticulum
Membrane
Oxidoreductase
Quinone
Redox-active center
Reference proteome
Transmembrane
Transmembrane helix