Names & Taxonomy

Uniprot ID:
Q8N0U8
Entry Name:
VKORL_HUMAN
Status:
reviewed
Protein Names:
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)
Gene Names:
VKORC1L1
Gene Names Primary:
VKORC1L1
Organism:
Homo sapiens (Human)

Structure

Length:
176
Sequence:
MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
Catalytic Activity:
Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by warfarin (coumadin).
Cross Reference Drug Bank:
DB00170
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
cellular response to oxidative stress
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process
Gene Ontology Biological Process:
cellular response to oxidative stress
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process
Gene Ontology Molecular Function:
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Disulfide bond
Endoplasmic reticulum
Membrane
Oxidoreductase
Quinone
Redox-active center
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
14765194 14702039 12853948 15489334 17974005 21269460 21367861 22814378 23928358 24532791 25944712