Names & Taxonomy

Uniprot ID:
Q8IVL5
Entry Name:
P3H2_HUMAN
Status:
reviewed
Protein Names:
Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)
Gene Names:
P3H2 LEPREL1 MLAT4
Gene Names Primary:
P3H2
Organism:
Homo sapiens (Human)

Structure

Length:
708
Sequence:
MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYASGAAAYYSGDYERAVRDLEAALRSHRRLREIRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRARCYRSCETQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGKHELNINPKDEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum

Function

Function:
Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.
Catalytic Activity:
L-proline- + 2-oxoglutarate + O(2) = trans-3-hydroxy-L-proline- + succinate + CO(2).
Cofactor:
COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Active Site:
ACT_SITE 662 662
Cross Reference Drug Bank:
DB00172 DB00139 DB00126
Gene Ontology Go:
basement membrane
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus
iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity
collagen metabolic process
extracellular matrix organization
negative regulation of cell proliferation
peptidyl-proline hydroxylation
Gene Ontology Biological Process:
collagen metabolic process
extracellular matrix organization
negative regulation of cell proliferation
peptidyl-proline hydroxylation
Gene Ontology Molecular Function:
iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity
Gene Ontology Cellular Component:
basement membrane
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus
Keywords:
Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Iron
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C

Publication

PubMed ID:
10449603 15063763 14702039 16641997 15489334 16959974 21885030