Names & Taxonomy
- Uniprot ID:
- Q8IVL5
- Entry Name:
- P3H2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)
- Gene Names:
- P3H2 LEPREL1 MLAT4
- Gene Names Primary:
- P3H2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 708
- Sequence:
- MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYASGAAAYYSGDYERAVRDLEAALRSHRRLREIRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRARCYRSCETQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGKHELNINPKDEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.
- Catalytic Activity:
- L-proline- + 2-oxoglutarate + O(2) = trans-3-hydroxy-L-proline- + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Active Site:
- ACT_SITE 662 662
- Cross Reference Drug Bank:
- DB00172 DB00139 DB00126
- Gene Ontology Go:
- basement membrane
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus
iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity
collagen metabolic process
extracellular matrix organization
negative regulation of cell proliferation
peptidyl-proline hydroxylation - Gene Ontology Biological Process:
- collagen metabolic process
extracellular matrix organization
negative regulation of cell proliferation
peptidyl-proline hydroxylation - Gene Ontology Molecular Function:
- iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity - Gene Ontology Cellular Component:
- basement membrane
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus - Keywords:
- Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Iron
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C