Names & Taxonomy

Uniprot ID:
Q8IV08
Entry Name:
PLD3_HUMAN
Status:
reviewed
Protein Names:
Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3)
Gene Names:
PLD3
Gene Names Primary:
PLD3
Organism:
Homo sapiens (Human)

Structure

Length:
490
Sequence:
MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Probably involved in APP processing.
Catalytic Activity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Active Site:
ACT_SITE 201 201
Gene Ontology Go:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
N-acylphosphatidylethanolamine-specific phospholipase D activity
phospholipase D activity
glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
N-acylphosphatidylethanolamine-specific phospholipase D activity
phospholipase D activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
Keywords:
Alzheimer disease
Amyloidosis
Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Neurodegeneration
Reference proteome
Repeat
Signal-anchor
Transmembrane
Transmembrane helix
Interacts With:
P19838

Publication

PubMed ID:
9140189 15489334 15794758 19159218 21269460 24275569 24336208 25832408 25832410 25944712 25832411 25832413 25832409