Names & Taxonomy
- Uniprot ID:
- Q86XM0
- Entry Name:
- CTSRD_HUMAN
- Status:
- reviewed
- Protein Names:
- Cation channel sperm-associated protein subunit delta (CatSper-delta) (CatSperdelta) (Transmembrane protein 146)
- Gene Names:
- CATSPERD TMEM146
- Gene Names Primary:
- CATSPERD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 798
- Sequence:
- MLMLMLVAAVTMWLRPLVTAQLCRSRTVRTGKVFNLIQDVQGDRLYFHPTTTRLIKHPCEKNIALYLGKQVFFTMDNFETSLLPFTIPTSMQVGVPEVTSAHFAGSLLLLVVDQKVYIYDYENNSWSMSLGIKHPVTHVSGDNCCYTGSLFCVHVSNLVFAYFRGDQISQTYIYYSNTGGFSFWKYHYDRQAEIIGSLGGIFHFFSLSQVAMLVVNQGKGMFKYSDHPLNRSFGLSFDYNGTLDILIAPGQRGILLLWFENSLLFSHNAGQLVDTVRVKKGDQTLFSSIFEAKITIHNIAVTENELAVITREDNLYYGNLGIVPSSIIKFADQYIWSEDVALMFRSPGTLEILTPLRDTAFPAFDFQKCLVNIQALLMDPELHVGKCKIEFLTGEFIYRMYTIDMHSQLELTASLIPQPGTSLIPLVMVSNPHSLGFQATFYENGYTSDGNTKYKLDIFLKQQQHWGRTDSNFTSSLKKATMSTLTVDIANKEISCVDIKPLSTLISVGCDLDKKIVIQNKVSACSMGILDPLTLQDNYSFIIEKEFYDPGFQGQQSSEDLHVFYSYQQLGCPLLVYYDTLWKPVVELWRKDSFQEVIDAEYVLLEVNGQFSYSYSLTAQSAMCTSQPQNWTTMIKEFGGPFFWNRENYVSCHDPNNNAPLRWPDVQYQILGGRTANQIIFGHNGFYVFYISIVDPYYSYCQLETIFSIYVYGAFPVQLVSAGVVILLIISSILGSVWLAYKTPKLLRTARGRRIKKCATQLCRRCKTVCQFRASATARAGTEPPGRHRTPHGGRSDH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell projection, cilium, flagellum membrane
Function
- Function:
- Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity).
- Gene Ontology Go:
- CatSper complex
plasma membrane
sperm principal piece
multicellular organism development
multicellular organism reproduction
single fertilization
sperm capacitation
sperm motility
sperm-egg recognition
spermatogenesis - Gene Ontology Biological Process:
- multicellular organism development
multicellular organism reproduction
single fertilization
spermatogenesis
sperm capacitation
sperm-egg recognition
sperm motility - Gene Ontology Cellular Component:
- CatSper complex
plasma membrane
sperm principal piece - Keywords:
- Alternative splicing
Cell membrane
Cell projection
Cilium
Complete proteome
Developmental protein
Differentiation
Flagellum
Glycoprotein
Membrane
Polymorphism
Reference proteome
Signal
Spermatogenesis
Transmembrane
Transmembrane helix - Interacts With:
- Q8TBB1