Names & Taxonomy
- Uniprot ID:
- Q86XK2
- Entry Name:
- FBX11_HUMAN
- Status:
- reviewed
- Protein Names:
- F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)
- Gene Names:
- FBXO11 FBX11 PRMT9 VIT1 UG063H01
- Gene Names Orf:
- UG063H01
- Gene Names Primary:
- FBXO11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 927
- Sequence:
- MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQQQPPPPPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Chromosome.
Function
- Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- chromosome
cytoplasm
nucleolus
nucleus
ubiquitin ligase complex
protein-arginine N-methyltransferase activity
ubiquitin-protein transferase activity
zinc ion binding
cellular protein modification process
peptidyl-arginine N-methylation
protein ubiquitination
sensory perception of sound
ubiquitin-dependent protein catabolic process - Gene Ontology Biological Process:
- cellular protein modification process
peptidyl-arginine N-methylation
protein ubiquitination
sensory perception of sound
ubiquitin-dependent protein catabolic process - Gene Ontology Molecular Function:
- protein-arginine N-methyltransferase activity
ubiquitin-protein transferase activity
zinc ion binding - Gene Ontology Cellular Component:
- chromosome
cytoplasm
nucleolus
nucleus
ubiquitin ligase complex - Keywords:
- Alternative splicing
Chromosome
Complete proteome
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Ubl conjugation pathway
Zinc
Zinc-finger - Interacts With:
- P63208; O95863; P04637