Names & Taxonomy
- Uniprot ID:
- Q86W47
- Entry Name:
- KCMB4_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Hbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4)
- Gene Names:
- KCNMB4
- Gene Names Primary:
- KCNMB4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 210
- Sequence:
- MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
- Cross Reference Drug Bank:
- DB01110 DB00721
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
potassium channel regulator activity
action potential
blood coagulation
detection of calcium ion
neuronal action potential
potassium ion transmembrane transport
potassium ion transport
regulation of neurotransmitter secretion
regulation of vasoconstriction
synaptic transmission - Gene Ontology Biological Process:
- action potential
blood coagulation
detection of calcium ion
neuronal action potential
potassium ion transmembrane transport
potassium ion transport
regulation of neurotransmitter secretion
regulation of vasoconstriction
synaptic transmission - Gene Ontology Molecular Function:
- calcium-activated potassium channel activity
potassium channel regulator activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport