Names & Taxonomy
- Uniprot ID:
- Q86UW1
- Entry Name:
- OSTA_HUMAN
- Status:
- reviewed
- Protein Names:
- Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha)
- Gene Names:
- SLC51A OSTA
- Gene Names Primary:
- SLC51A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 340
- Sequence:
- MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane
Function
- Function:
- Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
- Cross Reference Drug Bank:
- DB00286 DB00390 DB00917
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
plasma membrane
protein complex
protein heterodimerization activity
protein homodimerization activity
transporter activity
bile acid and bile salt transport
transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
transport - Gene Ontology Molecular Function:
- protein heterodimerization activity
protein homodimerization activity
transporter activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
plasma membrane
protein complex - Keywords:
- Cell membrane
Complete proteome
Endoplasmic reticulum
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport