Names & Taxonomy
- Uniprot ID:
- Q7Z2H8
- Entry Name:
- S36A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1)
- Gene Names:
- SLC36A1 PAT1
- Gene Names Primary:
- SLC36A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB00145 DB08847 DB00160 DB08835 DB01080
- Gene Ontology Go:
- endoplasmic reticulum
integral component of membrane
lysosomal membrane
plasma membrane
glycine transmembrane transporter activity
hydrogen ion transmembrane transporter activity
hydrogen:amino acid symporter activity
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity
amino acid transport
glycine transport
ion transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
glycine transport
ion transport
transmembrane transport - Gene Ontology Molecular Function:
- glycine transmembrane transporter activity
hydrogen:amino acid symporter activity
hydrogen ion transmembrane transporter activity
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
integral component of membrane
lysosomal membrane
plasma membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Lysosome
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport