Names & Taxonomy
- Uniprot ID:
- Q7Y7K9
- Entry Name:
- Q7Y7K9_HUMAN
- Status:
- unreviewed
- Protein Names:
- Cytochrome c oxidase subunit 1 (EC 1.9.3.1)
- Gene Names:
- COX1 COI coxI
- Gene Names Primary:
- COX1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 513
- Sequence:
- MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASATVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
- Pathway:
- Energy metabolism; oxidative phosphorylation.
- Catalytic Activity:
- 4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
respiratory chain
cytochrome-c oxidase activity
heme binding
iron ion binding
aerobic respiration
oxidative phosphorylation - Gene Ontology Biological Process:
- aerobic respiration
oxidative phosphorylation - Gene Ontology Molecular Function:
- cytochrome-c oxidase activity
heme binding
iron ion binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
respiratory chain - Keywords:
- Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport
Publication
- PubMed ID:
- 11938495 12870132 12840039 15382008 15467980 15466285 14760490 15890885 16172508 16714301 16855009 18398433 19083815 18461126 18545700 19573232 19624810 19331681 19158811 19823670 19955425 20643099 19844259 19755666 20643865 20713468 22365151 22482806 22560092 23206491 22130971 22363811 22517755 22079233 23756438 24002810 24121720 24244704 24341918 24607387 24467713 25301575 24713204 25254093 24498190 26428318 25826227 26781090 26875094