Names & Taxonomy
- Uniprot ID:
- Q7L3T8
- Entry Name:
- SYPM_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)
- Gene Names:
- PARS2
- Gene Names Primary:
- PARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 475
- Sequence:
- MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- mitochondrial matrix
ATP binding
proline-tRNA ligase activity
gene expression
prolyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
prolyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
proline-tRNA ligase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- ATP-binding
Aminoacyl-tRNA synthetase
Complete proteome
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide