Names & Taxonomy

Uniprot ID:
Q7L3T8
Entry Name:
SYPM_HUMAN
Status:
reviewed
Protein Names:
Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)
Gene Names:
PARS2
Gene Names Primary:
PARS2
Organism:
Homo sapiens (Human)

Structure

Length:
475
Sequence:
MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Catalytic Activity:
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
Cross Reference Drug Bank:
DB00172
Gene Ontology Go:
mitochondrial matrix
ATP binding
proline-tRNA ligase activity
gene expression
prolyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
prolyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
ATP binding
proline-tRNA ligase activity
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
ATP-binding
Aminoacyl-tRNA synthetase
Complete proteome
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
14702039 16710414 15489334 17974005 24275569