Names & Taxonomy

Uniprot ID:
Q7KZA3
Entry Name:
Q7KZA3_HUMAN
Status:
unreviewed
Protein Names:
Ferrochelatase (EC 4.99.1.1)
Gene Names:
DKFZp686P18130
Gene Names Primary:
DKFZp686P18130
Organism:
Homo sapiens (Human)

Structure

Length:
416
Sequence:
MAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL

Function

Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Pathway:
Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
Catalytic Activity:
Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
Cross Reference Drug Bank:
DB02659
Gene Ontology Go:
ferrochelatase activity
heme biosynthetic process
Gene Ontology Biological Process:
heme biosynthetic process
Gene Ontology Molecular Function:
ferrochelatase activity
Keywords:
Heme biosynthesis
Iron
Lyase
Porphyrin biosynthesis