Names & Taxonomy
- Uniprot ID:
- Q6XPS3
- Entry Name:
- TPTE2_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)
- Gene Names:
- TPTE2 TPIP
- Gene Names Primary:
- TPTE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 522
- Sequence:
- MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Catalytic Activity:
- Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
- Active Site:
- ACT_SITE 320 320 Phosphocysteine intermediate.
- Gene Ontology Go:
- endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
Golgi membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Hydrolase
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix