Names & Taxonomy

Uniprot ID:
Q6XPS3
Entry Name:
TPTE2_HUMAN
Status:
reviewed
Protein Names:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)
Gene Names:
TPTE2 TPIP
Gene Names Primary:
TPTE2
Organism:
Homo sapiens (Human)

Structure

Length:
522
Sequence:
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Catalytic Activity:
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
Active Site:
ACT_SITE 320 320 Phosphocysteine intermediate.
Gene Ontology Go:
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Hydrolase
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11716755 14659893 14702039 22164291 15057823 15489334