Names & Taxonomy

Uniprot ID:
Q6W5P4
Entry Name:
NPSR1_HUMAN
Status:
reviewed
Protein Names:
Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility)
Gene Names:
NPSR1 GPR154 GPRA PGR14
Gene Names Primary:
NPSR1
Organism:
Homo sapiens (Human)

Structure

Length:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane

Function

Function:
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
Cross Reference Drug Bank:
DB01159
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
plasma membrane
neuropeptide receptor activity
vasopressin receptor activity
neuropeptide signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
Gene Ontology Biological Process:
neuropeptide signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
Gene Ontology Molecular Function:
neuropeptide receptor activity
vasopressin receptor activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Asthma
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
15073379 15947423 14702039 15489334 15312648 15710598 15764725 16790440