Names & Taxonomy
- Uniprot ID:
- Q6U841
- Entry Name:
- S4A10_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)
- Gene Names:
- SLC4A10 NCBE
- Gene Names Primary:
- SLC4A10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1118
- Sequence:
- MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDLLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTALWRNLLITADNSKDKESSFPSKSSPS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane.
Function
- Function:
- Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).
- Cross Reference Drug Bank:
- DB01390
- Gene Ontology Go:
- apical dendrite
basilar dendrite
basolateral plasma membrane
CA3 pyramidal cell dendrite
integral component of membrane
neuronal cell body
plasma membrane
anion transmembrane transporter activity
inorganic anion exchanger activity
symporter activity
anion transmembrane transport
bicarbonate transport
brain morphogenesis
chloride transport
hydrogen ion transmembrane transport
ion transport
locomotory exploration behavior
multicellular organism growth
post-embryonic development
pyramidal neuron development
regulation of cellular pH
response to light stimulus
sodium ion transport
transmembrane transport - Gene Ontology Biological Process:
- anion transmembrane transport
bicarbonate transport
brain morphogenesis
chloride transport
hydrogen ion transmembrane transport
ion transport
locomotory exploration behavior
multicellular organism growth
post-embryonic development
pyramidal neuron development
regulation of cellular pH
response to light stimulus
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- anion transmembrane transporter activity
inorganic anion exchanger activity
symporter activity - Gene Ontology Cellular Component:
- apical dendrite
basilar dendrite
basolateral plasma membrane
CA3 pyramidal cell dendrite
integral component of membrane
neuronal cell body
plasma membrane - Keywords:
- Alternative splicing
Antiport
Cell membrane
Complete proteome
Ion transport
Membrane
Phosphoprotein
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport