Names & Taxonomy

Uniprot ID:
Q6TGC4
Entry Name:
PADI6_HUMAN
Status:
reviewed
Protein Names:
Protein-arginine deiminase type-6 (EC 3.5.3.15) (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI)
Gene Names:
PADI6 PAD6
Gene Names Primary:
PADI6
Organism:
Homo sapiens (Human)

Structure

Length:
694
Sequence:
MVSVEGRAMSFQSIIHLSLDSPVHAVCVLGTEICLDLSGCAPQKCQCFTIHGSGRVLIDVANTVISEKEDATIWWPLSDPTYATVKMTSPSPSVDADKVSVTYYGPNEDAPVGTAVLYLTGIEVSLEVDIYRNGQVEMSSDKQAKKKWIWGPSGWGAILLVNCNPADVGQQLEDKKTKKVIFSEEITNLSQMTLNVQGPSCILKKYRLVLHTSKEESKKARVYWPQKDNSSTFELVLGPDQHAYTLALLGNHLKETFYVEAIAFPSAEFSGLISYSVSLVEESQDPSIPETVLYKDTVVFRVAPCVFIPCTQVPLEVYLCRELQLQGFVDTVTKLSEKSNSQVASVYEDPNRLGRWLQDEMAFCYTQAPHKTTSLILDTPQAADLDEFPMKYSLSPGIGYMIQDTEDHKVASMDSIGNLMVSPPVKVQGKEYPLGRVLIGSSFYPSAEGRAMSKTLRDFLYAQQVQAPVELYSDWLMTGHVDEFMCFIPTDDKNEGKKGFLLLLASPSACYKLFREKQKEGYGDALLFDELRADQLLSNGREAKTIDQLLADESLKKQNEYVEKCIHLNRDILKTELGLVEQDIIEIPQLFCLEKLTNIPSDQQPKRSFARPYFPDLLRMIVMGKNLGIPKPFGPQIKGTCCLEEKICCLLEPLGFKCTFINDFDCYLTEVGDICACANIRRVPFAFKWWKMVP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).
Catalytic Activity:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Cross Reference Drug Bank:
DB00155
Gene Ontology Go:
cytoplasm
intermediate filament cytoskeleton
nucleus
calcium ion binding
protein-arginine deiminase activity
cytoplasm organization
cytoskeleton organization
protein citrullination
regulation of translation by machinery localization
Gene Ontology Biological Process:
cytoplasm organization
cytoskeleton organization
protein citrullination
regulation of translation by machinery localization
Gene Ontology Molecular Function:
calcium ion binding
protein-arginine deiminase activity
Gene Ontology Cellular Component:
cytoplasm
intermediate filament cytoskeleton
nucleus
Keywords:
3D-structure
Calcium
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Phosphoprotein
Reference proteome

Publication

PubMed ID:
15625577 15087120 22634725