Names & Taxonomy
- Uniprot ID:
- Q6PI48
- Entry Name:
- SYDM_HUMAN
- Status:
- reviewed
- Protein Names:
- Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)
- Gene Names:
- DARS2
- Gene Names Primary:
- DARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 645
- Sequence:
- MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKAERAH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
nucleus
aspartate-tRNA ligase activity
aspartate-tRNA(Asn) ligase activity
ATP binding
protein homodimerization activity
tRNA binding
gene expression
mitochondrial asparaginyl-tRNA aminoacylation
tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
mitochondrial asparaginyl-tRNA aminoacylation
tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- aspartate-tRNA(Asn) ligase activity
aspartate-tRNA ligase activity
ATP binding
protein homodimerization activity
tRNA binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide