Names & Taxonomy

Uniprot ID:
Q6PI48
Entry Name:
SYDM_HUMAN
Status:
reviewed
Protein Names:
Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)
Gene Names:
DARS2
Gene Names Primary:
DARS2
Organism:
Homo sapiens (Human)

Structure

Length:
645
Sequence:
MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKAERAH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Catalytic Activity:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
Cross Reference Drug Bank:
DB00128
Gene Ontology Go:
mitochondrial matrix
mitochondrion
nucleus
aspartate-tRNA ligase activity
aspartate-tRNA(Asn) ligase activity
ATP binding
protein homodimerization activity
tRNA binding
gene expression
mitochondrial asparaginyl-tRNA aminoacylation
tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
mitochondrial asparaginyl-tRNA aminoacylation
tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
aspartate-tRNA(Asn) ligase activity
aspartate-tRNA ligase activity
ATP binding
protein homodimerization activity
tRNA binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
nucleus
Keywords:
3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
16710414 15489334 15779907 19608861 21269460 24275569 25944712 17384640