Names & Taxonomy
- Uniprot ID:
- Q6NUM9
- Entry Name:
- RETST_HUMAN
- Status:
- reviewed
- Protein Names:
- All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)
- Gene Names:
- RETSAT PPSIG UNQ439/PRO872
- Gene Names Orf:
- UNQ439/PRO872
- Gene Names Primary:
- RETSAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 610
- Sequence:
- MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGIHYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
- Catalytic Activity:
- All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.
- Cofactor:
- COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
membrane
nuclear membrane
nuclear outer membrane
all-trans-retinol 13,14-reductase activity
oxidoreductase activity
oxidation-reduction process
retinol metabolic process - Gene Ontology Biological Process:
- oxidation-reduction process
retinol metabolic process - Gene Ontology Molecular Function:
- all-trans-retinol 13,14-reductase activity
oxidoreductase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
membrane
nuclear membrane
nuclear outer membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
FAD
Flavoprotein
Membrane
NAD
NADP
Oxidoreductase
Polymorphism
Reference proteome
Signal