Names & Taxonomy
- Uniprot ID:
- Q695T7
- Entry Name:
- S6A19_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)
- Gene Names:
- SLC6A19 B0AT1
- Gene Names Primary:
- SLC6A19
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 634
- Sequence:
- MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium-dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
- Gene Ontology Go:
- brush border membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
neurotransmitter:sodium symporter activity
neutral amino acid transmembrane transporter activity
amino acid transport
ion transport
response to nutrient
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
ion transport
response to nutrient
transmembrane transport - Gene Ontology Molecular Function:
- neurotransmitter:sodium symporter activity
neutral amino acid transmembrane transporter activity - Gene Ontology Cellular Component:
- brush border membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Amino-acid transport
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport