Names & Taxonomy
- Uniprot ID:
- Q5VTY9
- Entry Name:
- HHAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)
- Gene Names:
- HHAT MART2 SKI1
- Gene Names Primary:
- HHAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 493
- Sequence:
- MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYATD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
- Intramembrane:
- INTRAMEM 95 119
Function
- Function:
- Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.
- Active Site:
- ACT_SITE 379 379
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
GTP binding
palmitoyltransferase activity
multicellular organism development
positive regulation of protein targeting to mitochondrion
protein palmitoylation
smoothened signaling pathway - Gene Ontology Biological Process:
- multicellular organism development
positive regulation of protein targeting to mitochondrion
protein palmitoylation
smoothened signaling pathway - Gene Ontology Molecular Function:
- GTP binding
palmitoyltransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acyltransferase
Alternative splicing
Complete proteome
Developmental protein
Endoplasmic reticulum
GTP-binding
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix