Names & Taxonomy
- Uniprot ID:
- Q5FVE4
- Entry Name:
- ACBG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Bubblegum-related protein) (PRTD-NY3)
- Gene Names:
- ACSBG2 BGR UNQ2443/PRO5005
- Gene Names Orf:
- UNQ2443/PRO5005
- Gene Names Primary:
- ACSBG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 666
- Sequence:
- MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Membrane; Peripheral membrane protein.
Function
- Function:
- Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
- Catalytic Activity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
- Gene Ontology Go:
- cytoplasm
cytosol
membrane
mitochondrion
acyl-CoA hydrolase activity
ATP binding
long-chain fatty acid-CoA ligase activity
cell differentiation
cellular lipid metabolic process
fatty acid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
multicellular organism development
small molecule metabolic process
spermatogenesis
triglyceride biosynthetic process - Gene Ontology Biological Process:
- cell differentiation
cellular lipid metabolic process
fatty acid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
multicellular organism development
small molecule metabolic process
spermatogenesis
triglyceride biosynthetic process - Gene Ontology Molecular Function:
- acyl-CoA hydrolase activity
ATP binding
long-chain fatty acid-CoA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
membrane
mitochondrion - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Fatty acid metabolism
Ligase
Lipid metabolism
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Spermatogenesis