Names & Taxonomy
- Uniprot ID:
- Q547U9
- Entry Name:
- Q547U9_HUMAN
- Status:
- unreviewed
- Protein Names:
- Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (NMDA receptor subtype 2A gene)
- Gene Names:
- NR2A GRIN2A hCG_14641
- Gene Names Orf:
- hCG_14641
- Gene Names Primary:
- NR2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1464
- Sequence:
- MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane
Function
- Gene Ontology Go:
- cell junction
cell surface
endoplasmic reticulum
neuron projection
neuronal postsynaptic density
NMDA selective glutamate receptor complex
postsynaptic membrane
presynaptic membrane
synaptic vesicle
calcium channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity
directional locomotion
dopamine metabolic process
excitatory postsynaptic potential
long-term synaptic potentiation
memory
negative regulation of protein catabolic process
neurogenesis
positive regulation of apoptotic process
positive regulation of long-term synaptic potentiation
protein localization
regulation of sensory perception of pain
response to amphetamine
response to drug
response to ethanol
response to wounding
sensory perception of pain
serotonin metabolic process
sleep
startle response
visual learning - Gene Ontology Biological Process:
- directional locomotion
dopamine metabolic process
excitatory postsynaptic potential
long-term synaptic potentiation
memory
negative regulation of protein catabolic process
neurogenesis
positive regulation of apoptotic process
positive regulation of long-term synaptic potentiation
protein localization
regulation of sensory perception of pain
response to amphetamine
response to drug
response to ethanol
response to wounding
sensory perception of pain
serotonin metabolic process
sleep
startle response
visual learning - Gene Ontology Molecular Function:
- calcium channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity - Gene Ontology Cellular Component:
- cell junction
cell surface
endoplasmic reticulum
neuronal postsynaptic density
neuron projection
NMDA selective glutamate receptor complex
postsynaptic membrane
presynaptic membrane
synaptic vesicle - Keywords:
- Cell junction
Cell membrane
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Postsynaptic cell membrane
Receptor
Signal
Synapse
Transmembrane
Transmembrane helix
Transport