Names & Taxonomy
- Uniprot ID:
- Q53YE7
- Entry Name:
- Q53YE7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Amine oxidase [flavin-containing] (EC 1.4.3.4) (Monoamine oxidase)
- Gene Names:
- MAOA hCG_16826
- Gene Names Orf:
- hCG_16826
- Gene Names Primary:
- MAOA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 527
- Sequence:
- MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane
Function
- Function:
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
- Catalytic Activity:
- RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Gene Ontology Go:
- integral component of membrane
mitochondrial outer membrane
mitochondrion
flavin adenine dinucleotide binding
primary amine oxidase activity
serotonin binding
dopamine catabolic process
phenylethylamine metabolic process
serotonin metabolic process - Gene Ontology Biological Process:
- dopamine catabolic process
phenylethylamine metabolic process
serotonin metabolic process - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
primary amine oxidase activity
serotonin binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial outer membrane
mitochondrion - Keywords:
- Acetylation
FAD
Flavoprotein
Membrane
Mitochondrion
Mitochondrion outer membrane
Oxidoreductase
Publication
- PubMed ID:
- 11181995