Names & Taxonomy
- Uniprot ID:
- Q495M3
- Entry Name:
- S36A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Tramdorin-1)
- Gene Names:
- SLC36A2 PAT2 TRAMD1
- Gene Names Primary:
- SLC36A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 483
- Sequence:
- MSVTKSTEGPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFSNSTTFVR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cytoplasm
Function
- Function:
- Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity).
- Cross Reference Drug Bank:
- DB00260
- Gene Ontology Go:
- cytoplasm
extracellular exosome
integral component of membrane
plasma membrane
glycine transmembrane transporter activity
hydrogen ion transmembrane transporter activity
hydrogen:amino acid symporter activity
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity
amino acid transport
hydrogen ion transmembrane transport
ion transport
proline transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
hydrogen ion transmembrane transport
ion transport
proline transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- glycine transmembrane transporter activity
hydrogen:amino acid symporter activity
hydrogen ion transmembrane transporter activity
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Cytoplasm
Disease mutation
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport