Names & Taxonomy
- Uniprot ID:
- A0A0A0MSP0
- Entry Name:
- A0A0A0MSP0_HUMAN
- Status:
- unreviewed
- Protein Names:
- Calcium-transporting ATPase (EC 3.6.3.8)
- Gene Names:
- ATP2C2
- Gene Names Primary:
- ATP2C2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 975
- Sequence:
- MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGESTWAGRAGLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Gene Ontology Go:
- cytoplasmic side of plasma membrane
cytoplasmic vesicle
integral component of membrane
perinuclear region of cytoplasm
ATP binding
calcium-transporting ATPase activity
metal ion binding
mammary gland epithelium development
positive regulation of calcium ion import
protein targeting to plasma membrane - Gene Ontology Biological Process:
- mammary gland epithelium development
positive regulation of calcium ion import
protein targeting to plasma membrane - Gene Ontology Molecular Function:
- ATP binding
calcium-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- cytoplasmic side of plasma membrane
cytoplasmic vesicle
integral component of membrane
perinuclear region of cytoplasm - Keywords:
- ATP-binding
Calcium
Calcium transport
Complete proteome
Hydrolase
Ion transport
Membrane
Nucleotide-binding
Proteomics identification
Reference proteome
Transmembrane
Transmembrane helix
Transport