Names & Taxonomy
- Uniprot ID:
- Q32M45
- Entry Name:
- ANO4_HUMAN
- Status:
- reviewed
- Protein Names:
- Anoctamin-4 (Transmembrane protein 16D)
- Gene Names:
- ANO4 TMEM16D
- Gene Names Primary:
- ANO4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 955
- Sequence:
- MEASSSGITNGKTKVFHPEGGVDLQGYQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPERNKSNGLYFRDGKCRIDYILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.
- Gene Ontology Go:
- integral component of membrane
intracellular
plasma membrane
intracellular calcium activated chloride channel activity
phospholipid scramblase activity
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
chloride transmembrane transport
chloride transport
ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
chloride transmembrane transport
chloride transport
ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- intracellular calcium activated chloride channel activity
phospholipid scramblase activity - Gene Ontology Cellular Component:
- integral component of membrane
intracellular
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Lipid transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport