Names & Taxonomy
- Uniprot ID:
- Q2M3T9
- Entry Name:
- HYAL4_HUMAN
- Status:
- reviewed
- Protein Names:
- Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4)
- Gene Names:
- HYAL4
- Gene Names Primary:
- HYAL4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 481
- Sequence:
- MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQCLIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQGVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCPEDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYALPVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFVSSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVKGKASDTDLAVMADTFSCHCYQGYEGADCREIKTADGCSGVSPSPGSLMTLCLLLLASYRSIQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.
- Catalytic Activity:
- Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
- Active Site:
- ACT_SITE 147 147 Proton donor.
- Gene Ontology Go:
- cell surface
integral component of membrane
hyalurononglucosaminidase activity
carbohydrate metabolic process
chondroitin sulfate catabolic process
glycosaminoglycan catabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
chondroitin sulfate catabolic process
glycosaminoglycan catabolic process - Gene Ontology Molecular Function:
- hyalurononglucosaminidase activity
- Gene Ontology Cellular Component:
- cell surface
integral component of membrane - Keywords:
- Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Glycosidase
Hydrolase
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix