Names & Taxonomy
- Uniprot ID:
- A0A024R0Y5
- Entry Name:
- A0A024R0Y5_HUMAN
- Status:
- unreviewed
- Protein Names:
- ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
- Gene Names:
- PFKM hCG_27714
- Gene Names Orf:
- hCG_27714
- Gene Names Primary:
- PFKM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 780
- Sequence:
- MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
- Catalytic Activity:
- ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
- Active Site:
- ACT_SITE 166 166 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
6-phosphofructokinase activity
ATP binding
metal ion binding
fructose 6-phosphate metabolic process - Gene Ontology Biological Process:
- fructose 6-phosphate metabolic process
- Gene Ontology Molecular Function:
- 6-phosphofructokinase activity
ATP binding
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- ATP-binding
Allosteric enzyme
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase
Publication
- PubMed ID:
- 11181995