Names & Taxonomy

Uniprot ID:
A0A024R0Y5
Entry Name:
A0A024R0Y5_HUMAN
Status:
unreviewed
Protein Names:
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
Gene Names:
PFKM hCG_27714
Gene Names Orf:
hCG_27714
Gene Names Primary:
PFKM
Organism:
Homo sapiens (Human)

Structure

Length:
780
Sequence:
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Pathway:
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
Catalytic Activity:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation:
ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
Active Site:
ACT_SITE 166 166 Proton acceptor.
Gene Ontology Go:
cytoplasm
6-phosphofructokinase activity
ATP binding
metal ion binding
fructose 6-phosphate metabolic process
Gene Ontology Biological Process:
fructose 6-phosphate metabolic process
Gene Ontology Molecular Function:
6-phosphofructokinase activity
ATP binding
metal ion binding
Gene Ontology Cellular Component:
cytoplasm
Keywords:
ATP-binding
Allosteric enzyme
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase

Publication

PubMed ID:
11181995