Names & Taxonomy
- Uniprot ID:
- Q16853
- Entry Name:
- AOC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
- Gene Names:
- AOC3 VAP1
- Gene Names Primary:
- AOC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 763
- Sequence:
- MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
- Catalytic Activity:
- RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.94 mM for 2-phenylethylamine
- Active Site:
- ACT_SITE 386 386 Proton acceptor.
- Cross Reference Drug Bank:
- DB01275 DB00780
- Gene Ontology Go:
- cell surface
cytoplasm
early endosome
endoplasmic reticulum
Golgi apparatus
integral component of membrane
microvillus
plasma membrane
aliphatic-amine oxidase activity
aminoacetone:oxygen oxidoreductase(deaminating) activity
calcium ion binding
copper ion binding
phenethylamine:oxygen oxidoreductase (deaminating) activity
primary amine oxidase activity
protein heterodimerization activity
protein homodimerization activity
quinone binding
tryptamine:oxygen oxidoreductase (deaminating) activity
amine metabolic process
cell adhesion
inflammatory response
response to antibiotic
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- amine metabolic process
cell adhesion
inflammatory response
response to antibiotic
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aliphatic-amine oxidase activity
aminoacetone:oxygen oxidoreductase(deaminating) activity
calcium ion binding
copper ion binding
phenethylamine:oxygen oxidoreductase (deaminating) activity
primary amine oxidase activity
protein heterodimerization activity
protein homodimerization activity
quinone binding
tryptamine:oxygen oxidoreductase (deaminating) activity - Gene Ontology Cellular Component:
- cell surface
cytoplasm
early endosome
endoplasmic reticulum
Golgi apparatus
integral component of membrane
microvillus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Complete proteome
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Signal-anchor
TPQ
Transmembrane
Transmembrane helix