Names & Taxonomy
- Uniprot ID:
- Q16836
- Entry Name:
- HCDH_HUMAN
- Status:
- reviewed
- Protein Names:
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)
- Gene Names:
- HADH HAD HADHSC SCHAD
- Gene Names Primary:
- HADH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 314
- Sequence:
- MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
- Pathway:
- Lipid metabolism; fatty acid beta-oxidation.
- Catalytic Activity:
- (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
- Gene Ontology Go:
- cytoplasm
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
nucleoplasm
3-hydroxyacyl-CoA dehydrogenase activity
NAD+ binding
cellular lipid metabolic process
fatty acid beta-oxidation
negative regulation of insulin secretion
response to activity
response to drug
response to insulin
small molecule metabolic process - Gene Ontology Biological Process:
- cellular lipid metabolic process
fatty acid beta-oxidation
negative regulation of insulin secretion
response to activity
response to drug
response to insulin
small molecule metabolic process - Gene Ontology Molecular Function:
- 3-hydroxyacyl-CoA dehydrogenase activity
NAD+ binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Fatty acid metabolism
Lipid metabolism
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide