Names & Taxonomy

Uniprot ID:
Q16798
Entry Name:
MAON_HUMAN
Status:
reviewed
Protein Names:
NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)
Gene Names:
ME3
Gene Names Primary:
ME3
Organism:
Homo sapiens (Human)

Structure

Length:
604
Sequence:
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Catalytic Activity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.; Oxaloacetate = pyruvate + CO(2).
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 137 137 Proton donor.
Gene Ontology Go:
mitochondrial matrix
mitochondrion
cofactor binding
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
aerobic respiration
malate metabolic process
oxidation-reduction process
oxygen metabolic process
pyruvate metabolic process
Gene Ontology Biological Process:
aerobic respiration
malate metabolic process
oxidation-reduction process
oxygen metabolic process
pyruvate metabolic process
Gene Ontology Molecular Function:
cofactor binding
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
Alternative splicing
Complete proteome
Metal-binding
Mitochondrion
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
7818469 14702039 16554811 15489334