Names & Taxonomy
- Uniprot ID:
- Q16798
- Entry Name:
- MAON_HUMAN
- Status:
- reviewed
- Protein Names:
- NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)
- Gene Names:
- ME3
- Gene Names Primary:
- ME3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 604
- Sequence:
- MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Catalytic Activity:
- (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.; Oxaloacetate = pyruvate + CO(2).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 137 137 Proton donor.
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
cofactor binding
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
aerobic respiration
malate metabolic process
oxidation-reduction process
oxygen metabolic process
pyruvate metabolic process - Gene Ontology Biological Process:
- aerobic respiration
malate metabolic process
oxidation-reduction process
oxygen metabolic process
pyruvate metabolic process - Gene Ontology Molecular Function:
- cofactor binding
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Alternative splicing
Complete proteome
Metal-binding
Mitochondrion
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide