Names & Taxonomy
- Uniprot ID:
- Q16790
- Entry Name:
- CAH9_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1)
- Gene Names:
- CA9 G250 MN
- Gene Names Primary:
- CA9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 459
- Sequence:
- MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 200 200 Proton acceptor.
- Cross Reference Drug Bank:
- DB00562 DB00999 DB00774 DB00909
- Gene Ontology Go:
- basolateral plasma membrane
integral component of membrane
microvillus membrane
nucleolus
plasma membrane
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
cellular response to hypoxia
morphogenesis of an epithelium
one-carbon metabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
response to drug
response to testosterone
secretion
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
cellular response to hypoxia
morphogenesis of an epithelium
one-carbon metabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
response to drug
response to testosterone
secretion
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of membrane
microvillus membrane
nucleolus
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc