Names & Taxonomy
- Uniprot ID:
- Q16775
- Entry Name:
- GLO2_HUMAN
- Status:
- reviewed
- Protein Names:
- Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)
- Gene Names:
- HAGH GLO2 HAGH1
- Gene Names Primary:
- HAGH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 308
- Sequence:
- MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Mitochondrion matrix
Function
- Function:
- Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
- Pathway:
- Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
- Catalytic Activity:
- S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrial matrix
hydroxyacylglutathione hydrolase activity
metal ion binding
carbohydrate metabolic process
cellular metabolic process
glutathione biosynthetic process
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
pyruvate metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular metabolic process
glutathione biosynthetic process
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
pyruvate metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- hydroxyacylglutathione hydrolase activity
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrial matrix - Keywords:
- 3D-structure
Acetylation
Alternative initiation
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc - Interacts With:
- Q9NYB0